TESTOSTERONE PROPIONATE is … What is TESTOSTERONE PROPIONATE?
Testosterone (male sex hormone) information
TESTOSTERONE PROPIONATE (Testostеroni propionas). Adrosten-4-ol-17 b-one-3 propionate. Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F, Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate, Testosteronum propionicum, Testoviron, Virormone, etc vigora100. White crystalline powder. Practically insoluble in water, easily soluble in alcohol, soluble in vegetable oils. Testosterone is an endogenous male sex (androgenic) hormone. It is produced in the male gonads, it is necessary for the formation of the genitals and the development of secondary sexual characteristics in men. Continuous production of testosterone begins during puberty and continues until the period of extinction of sexual function. According to modern data, there are specialized androgen receptors in the body. Testosterone circulating in the blood is converted in target organs into 5a-dihydrosterone (with the help of the 5a-reductase enzyme), which binds to androgen receptors and enters the cell nucleus. It is also possible that testosterone itself binds to receptors in some tissues. For use in medical practice, testosterone propionate is synthesized. It has the biological and medicinal properties of a natural hormone, but is absorbed more slowly and is more stable in the body than testosterone. Testosterone propionate is used parenterally; when taken orally, it is ineffective (rapidly destroyed in the liver). In addition to the specific androgenic effect, testosterone, like all androgens, has an effect on other functions and systems of the body, in particular, it affects nitrogen and phosphorus metabolism. It is anabolic and can be considered an endogenous anabolic hormone. An insufficient content of testosterone in the body (with insufficient sexual development, after castration, etc.) is usually accompanied by a violation of protein anabolism, atrophy of skeletal muscles and increased deposition in the subcutaneous tissue and internal organs of adipose tissue. Substitution of testosterone preparations can have a therapeutic effect with these changes. The anabolic effect of testosterone is also manifested in various pathological conditions, accompanied by increased breakdown of proteins (chronic infectious diseases, exhaustion, surgical interventions, severe trauma, etc.) and impaired calcium and phosphorus metabolism (osteoporosis). The widespread use of testosterone as an anabolic agent is hindered by its strong androgenic effect. Currently, drugs have been obtained that are close in chemical structure to testosterone, but have a more selective anabolic effect. Testosterone propionate is prescribed mainly to men with sexual underdevelopment, functional disorders in the reproductive system, climacteric syndrome, and acromegaly. In some cases, testosterone propionate has a positive effect on prostatic hypertrophy: the general condition improves, urination disorders decrease, etc. The administration of testosterone propionate, like other androgens, to women causes inhibition of the gonadotropic function of the pituitary gland, inhibition buy real testosterone online of the function of the follicular apparatus and ovaries, endometrial atrophy, suppression functions of the mammary glands. For medicinal purposes, testosterone propionate is sometimes used in women with climacteric vascular and nervous disorders in cases where estrogenic drugs are contraindicated (for tumors of the genital organs and mammary glands, uterine bleeding). It is also given concurrently with radiation therapy for breast and ovarian cancer (usually in women under the age of 60). In older women, testosterone propionate can be used for dysfunctional uterine bleeding. Testosterone propionate can also have a positive effect in the early stages of hypertension and angioneurotic forms of angina pectoris. In all cases, the drug is used only as directed by a doctor, and during treatment, the patient is closely monitored. Applied in the form of intramuscular or subcutaneous injections in oil solutions. Men with eunuchoidism, congenital underdevelopment of the gonads, their removal by surgery or as a result of injury, as well as with acromegaly, are prescribed 0.025 g (25 mg) daily or 0.05 g (50 mg) every other day or 2 days later. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. Usually, the treatment is carried out for a long time. After improvement of the clinical picture, testosterone propionate is administered in maintenance doses; 0.005 – 0.01 g daily or every other day, or switch to methyltestosterone ingestion. With impotence due to functional insufficiency of the gonads, overwork and nervous exhaustion, as well as with male climacteric syndrome, appoint 10 mg daily or 25 mg 2 – 3 times a week for 1 – 2 months. With prostatic hypertrophy in the initial stage, take 10 mg every other day for 1 – 2 months. Women over 45 with dysfunctional uterine bleeding are prescribed 0.01-0.025 g (10-25 mg) every other day for 20-30 days until the bleeding stops and atrophic cells appear in vaginal smears. Previously, malignant neoplasms of the uterus should be excluded. With vascular and nervous disorders of climacteric origin in women and the presence of contraindications to the use of estrogens, testosterone propionate is administered at 0.01 g (10 mg) every other day or 0.025 g (25 mg) 2 times a week for 2 to 3 weeks. It is preferable in these cases to prescribe methyltestosterone. Patients with angina pectoris sometimes have a positive effect when using testosterone at 10.0 – 12.5 mg 1 time per week; with good tolerance, the number of injections is increased to two per week (within 3 – 5 weeks). By the end of treatment, the dose and the number of injections are reduced again. The course of treatment consists of 15 to 20 injections. The positive effect is associated with the improvement of blood circulation and metabolic processes in the heart muscle; there are also favorable shifts in the lipid ratio in the blood, an increase in the lecithin / cholesterol ratio. The best result is observed with angioneurotic forms of angina pectoris. With severe cardiosclerosis, hormone treatment is ineffective. In malignant tumors of the breast or ovaries buy testosterone propionate, testosterone propionate is administered in a dose of 0.05 g (50 mg) daily for several months, then (depending on the results of treatment) the dose is reduced and maintenance doses are prescribed for a long time. As an addition to surgery or radiation therapy, the drug is prescribed for women under 60 years of age (older women are advised to take estrogens). Higher doses intramuscularly for adults: single 0.05 g (1 ml of 5% solution), daily 0.1 g (2 ml of 5% solution). When treating testosterone with propionate and other androgenic drugs, it is necessary to closely monitor the condition of patients: large doses can cause increased sexual arousal, water and salt retention in the body, dizziness, nausea; in women, the phenomena of masculinization (virilism) can be observed: coarsening of the voice, excessive growth of hair on the face and body, pasty face, atrophy of the mammary glands. An overdose of drugs for dysmenorrhea can lead to the cessation of menstruation. Androgenic drugs are contraindicated in prostate cancer. Release form: 1% or 5% solution in oil in 1 ml ampoules. Storage: List B. In a dark place.
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